Expression of PIGZ in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PIGZ
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class Z
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (colon, rectum)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Membranous expression in a subset of tissues including the gastrointestinal tract, gallbladder and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA058599 , HPA059920
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA058599	HPA059920

GENE INFORMATION
Gene name	PIGZ (HGNC Symbol)
Synonyms	FLJ12768, MGC52163, SMP3
Description	Phosphatidylinositol glycan anchor biosynthesis, class Z (HGNC Symbol)
Entrez gene summary	The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	196946343 - 196969060
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000119227 (version 83.38)
Entrez gene	80235
UniProt	Q86VD9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86VD9
Antibodypedia	PIGZ antibodies

PROTEIN BROWSER

PIGZ-001	PIGZ-002	PIGZ-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGZ-001 ENSP00000413405 ENST00000412723	Q86VD9 [Direct mapping] GPI mannosyltransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0000026 [alpha-1,2-mannosyltransferase activity] GO:0000030 [mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0097502 [mannosylation] Show all	579 aa 63.5 kDa	No	>9
PIGZ-002 ENSP00000405341 ENST00000413127	H7C2E0 [Direct mapping] GPI mannosyltransferase 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	49 aa 5.4 kDa	Yes	0
PIGZ-004 ENSP00000389327 ENST00000443835	C9JQX2 [Direct mapping] GPI mannosyltransferase 4 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	92 aa 10.1 kDa	No	0