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Weak to moderate cytoplasmic staining in most cancers.
Additional nuclear positivity was observed in most cancers. A few ovarian cancers showed strong immunoreactivity. Several squamous cell carcinomas and lymphomas were negative.
Most cancers displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Most skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
WDR34 (HGNC Symbol)
Synonyms
bA216B9.3, DIC5, FAP133, MGC20486
Description
WD repeat domain 34 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
Q96EX3 [Direct mapping] WD repeat-containing protein 34
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)