Cell atlas - GLE1 - The Human Protein Atlas

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GLE1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoli

Human cell
	Nuclear membrane
	Nucleoli

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GENERAL INFORMATION
Gene name	GLE1
Gene description	GLE1 RNA export mediator
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (supported)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061560
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the nucleoli.

Main location

Nuclear membrane (supported)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061560	A549	Nucleoli
	HPA061560	A549	Cytosol
	HPA061560	MCF7	Nuclear membrane
	HPA061560	MCF7	Nucleoli
	HPA061560	U-2 OS	Nuclear membrane
	HPA061560	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	GLE1 (HGNC Symbol)
Synonyms	GLE1L, hGLE1, LCCS1
Description	GLE1 RNA export mediator (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128504700 - 128542288
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119392 (version 83.38)
Entrez gene	2733
UniProt	Q53GS7 (UniProt - Evidence at protein level)
neXtProt	NX_Q53GS7
Antibodypedia	GLE1 antibodies

PROTEIN BROWSER

GLE1-001	GLE1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLE1-001 ENSP00000361856 ENST00000372770	Q53GS7 [Direct mapping] Nucleoporin GLE1 Show all	Transporters Transporter channels and pores Primary Active Transporters MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006406 [mRNA export from nucleus] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0042802 [identical protein binding] Show all	659 aa 75.4 kDa	No	0
GLE1-002 ENSP00000308622 ENST00000309971	Q53GS7 [Direct mapping] Nucleoporin GLE1 Show all	Transporters Transporter channels and pores Primary Active Transporters MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006406 [mRNA export from nucleus] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0042802 [identical protein binding] Show all	698 aa 79.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.