Expression of CNTRL in cancer - Summary - The Human Protein Atlas

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CNTRL

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNTRL
Gene description	Centriolin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA020468 , HPA020480 , HPA051583
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020468	HPA020480	HPA051583

GENE INFORMATION
Gene name	CNTRL (HGNC Symbol)
Synonyms	CEP1, CEP110
Description	Centriolin (HGNC Symbol)
Entrez gene summary	This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.2
Chromosome location (bp)	121074863 - 121177610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119397 (version 83.38)
Entrez gene	11064
UniProt	Q7Z7A1 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7A1
Antibodypedia	CNTRL antibodies

PROTEIN BROWSER

CNTRL-001	CNTRL-002	CNTRL-005	CNTRL-007	CNTRL-008	CNTRL-010	CNTRL-201	CNTRL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTRL-001 ENSP00000362956 ENST00000373850	Q7Z7A1 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0051301 [cell division] Show all	1773 aa 205.2 kDa	No	0
CNTRL-002 ENSP00000362953 ENST00000373847	Q5JVD1 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		994 aa 113.8 kDa	No	0
CNTRL-005 ENSP00000413014 ENST00000431571	Q5JVD6 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		346 aa 40.6 kDa	No	0
CNTRL-007 ENSP00000362950 ENST00000373844	Q5JVD5 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.9 kDa	No	0
CNTRL-008 ENSP00000362972 ENST00000373865	Q5JVD3 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	460 aa 53.1 kDa	No	0
CNTRL-010 ENSP00000362962 ENST00000373855	Q7Z7A1 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0003279 [cardiac septum development] GO:0003281 [ventricular septum development] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0035904 [aorta development] GO:0048471 [perinuclear region of cytoplasm] GO:0051301 [cell division] GO:0060976 [coronary vasculature development] Show all	2325 aa 268.9 kDa	No	0
CNTRL-201 ENSP00000238341 ENST00000238341	Q7Z7A1 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0051301 [cell division] Show all	2325 aa 268.9 kDa	No	0
CNTRL-202 ENSP00000481072 ENST00000613863	Q7Z7A1 [Direct mapping] Centriolin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0051301 [cell division] Show all	482 aa 56.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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