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NEK6

GENERAL INFORMATION

Gene name

 NEK6

Gene description

 NIMA-related kinase 6

Protein class

 Enzymes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types, most abundant in gallbladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB045993
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (unfavourable).
Testis cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB045993

GENE INFORMATION

Gene name

 NEK6 (HGNC Symbol)

Synonyms

 SID6-1512

Description

 NIMA-related kinase 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 9

Cytoband

 q33.3

Chromosome location (bp)

 124257606 - 124353307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119408 (version 83.38)

Entrez gene

 10783

UniProt

 Q9HC98 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC98

Antibodypedia

 NEK6 antibodies

PROTEIN BROWSER
«
NEK6-001
NEK6-002
NEK6-003
NEK6-004
NEK6-005
NEK6-006
NEK6-007
NEK6-008
NEK6-009
NEK6-010
NEK6-201
NEK6-202
NEK6-203
NEK6-204
NEK6-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK6-001
ENSP00000411401
ENST00000422297
Q5TBH2 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 220 aa
24.9 kDa 		No 0
NEK6-002
ENSP00000319734
ENST00000320246
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
A0A024R8A6 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 6, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 313 aa
35.7 kDa 		No 0
NEK6-003
ENSP00000362702
ENST00000373600
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 347 aa
39.8 kDa 		No 0
NEK6-004
ENSP00000362705
ENST00000373603
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
A0A024R8A6 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 6, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 313 aa
35.7 kDa 		No 0
NEK6-005
ENSP00000389517
ENST00000444973
Q5TBG7 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 219 aa
24.8 kDa 		No 0
NEK6-006
ENSP00000405215
ENST00000454453
Q5TBH0 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 201 aa
22.8 kDa 		No 0
NEK6-007
ENSP00000362698
ENST00000373596
Q5TBG1 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 207 aa
23.4 kDa 		No 0
NEK6-008
ENSP00000403087
ENST00000425237
Q5TBH1 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 222 aa
25.2 kDa 		No 0
NEK6-009
ENSP00000399847
ENST00000423785
Q5TBG4 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 194 aa
22.4 kDa 		No 0
NEK6-010
ENSP00000403414
ENST00000447379
Q5TBG2 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 171 aa
19.7 kDa 		No 0
NEK6-201
ENSP00000377749
ENST00000394199
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 347 aa
39.8 kDa 		No 0
NEK6-202
ENSP00000439651
ENST00000539416
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 338 aa
38.5 kDa 		No 0
NEK6-203
ENSP00000441469
ENST00000540326
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 331 aa
37.8 kDa 		No 0
NEK6-204
ENSP00000442636
ENST00000545174
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
A0A024R8A6 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 6, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 313 aa
35.7 kDa 		No 0
NEK6-205
ENSP00000441426
ENST00000546191
Q9HC98 [Direct mapping]
Serine/threonine-protein kinase Nek6
A0A024R8A6 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 6, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031572 [G2 DNA damage checkpoint]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046777 [protein autophosphorylation]
GO:0051225 [spindle assembly]
GO:2000772 [regulation of cellular senescence]
Show all
 313 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.