Expression of HDHD3 in cancer - Summary - The Human Protein Atlas

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HDHD3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HDHD3
Gene description	Haloacid dehalogenase-like hydrolase domain containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA020427 , HPA024158 , HPA024585
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020427	HPA024158	HPA024585

GENE INFORMATION
Gene name	HDHD3 (HGNC Symbol)
Synonyms	C9orf158, MGC12904
Description	Haloacid dehalogenase-like hydrolase domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q32
Chromosome location (bp)	113373419 - 113376999
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119431 (version 83.38)
Entrez gene	81932
UniProt	Q9BSH5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BSH5
Antibodypedia	HDHD3 antibodies

PROTEIN BROWSER

HDHD3-001	HDHD3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDHD3-001 ENSP00000238379 ENST00000238379	Q9BSH5 [Direct mapping] Haloacid dehalogenase-like hydrolase domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	251 aa 28 kDa	No	0
HDHD3-002 ENSP00000363295 ENST00000374180	Q9BSH5 [Direct mapping] Haloacid dehalogenase-like hydrolase domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	251 aa 28 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.