We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Nuclear receptor subfamily 4, group A, member 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Q92570 [Direct mapping] Nuclear receptor subfamily 4 group A member 3 A0A024R168 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 3, isoform CRA_c
Show all
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007369 [gastrulation] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0009444 [pyruvate oxidation] GO:0010467 [gene expression] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010828 [positive regulation of glucose transport] GO:0019901 [protein kinase binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032765 [positive regulation of mast cell cytokine production] GO:0035726 [common myeloid progenitor cell proliferation] GO:0038097 [positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043303 [mast cell degranulation] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044320 [cellular response to leptin stimulus] GO:0045333 [cellular respiration] GO:0045444 [fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046321 [positive regulation of fatty acid oxidation] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0061469 [regulation of type B pancreatic cell proliferation] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0097009 [energy homeostasis] GO:1900625 [positive regulation of monocyte aggregation] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:2000253 [positive regulation of feeding behavior] GO:2000505 [regulation of energy homeostasis]