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INVS

GENERAL INFORMATION

Gene name

 INVS

Gene description

 Inversin

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 INVS (HGNC Symbol)

Synonyms

 NPHP2

Description

 Inversin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]

Chromosome

 9

Cytoband

 q31.1

Chromosome location (bp)

 100099256 - 100301000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119509 (version 83.38)

Entrez gene

 27130

UniProt

 Q9Y283 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y283

Antibodypedia

 INVS antibodies

PROTEIN BROWSER
INVS-001
INVS-005
INVS-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INVS-001
ENSP00000262456
ENST00000262456
Q9Y283 [Direct mapping]
Inversin
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 895 aa
99.6 kDa 		No 0
INVS-005
ENSP00000262457
ENST00000262457
Q9Y283 [Direct mapping]
Inversin
A0A024R153 [Target identity:100%; Query identity:100%]
Inversin, isoform CRA_a
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0009791 [post-embryonic development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0031016 [pancreas development]
GO:0048513 [organ development]
GO:0060971 [embryonic heart tube left/right pattern formation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097543 [ciliary inversin compartment]
GO:0097546 [ciliary base]
Show all
 1065 aa
117.8 kDa 		No 0
INVS-006
ENSP00000364056
ENST00000374921
Q9Y283 [Direct mapping]
Inversin
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 101 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.