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ALG2

GENERAL INFORMATION

Gene name

 ALG2

Gene description

 ALG2, alpha-1,3/1,6-mannosyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues including glandular cells of seminal vesicle, epididymis, uterus and exocrine pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA041512 , HPA041601
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALG2 (HGNC Symbol)

Synonyms

 CDGIi, FLJ14511, hALPG2, NET38

Description

 ALG2, alpha-1,3/1,6-mannosyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

 9

Cytoband

 q22.33

Chromosome location (bp)

 99216426 - 99221956

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119523 (version 83.38)

Entrez gene

 85365

UniProt

 Q9H553 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H553

Antibodypedia

 ALG2 antibodies

PROTEIN BROWSER
ALG2-002
ALG2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALG2-002
ENSP00000417764
ENST00000476832
Q9H553 [Direct mapping]
Alpha-1,3/1,6-mannosyltransferase ALG2
A0A024R184 [Target identity:100%; Query identity:100%]
Asparagine-linked glycosylation 2 homolog (Yeast, alpha-1,3-mannosyltransferase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000033 [alpha-1,3-mannosyltransferase activity]
GO:0004378 [GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0033577 [protein glycosylation in endoplasmic reticulum]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051592 [response to calcium ion]
GO:0097502 [mannosylation]
Show all
 416 aa
47.1 kDa 		No 1
ALG2-201
ENSP00000326609
ENST00000319033
Q9H553 [Direct mapping]
Alpha-1,3/1,6-mannosyltransferase ALG2
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000033 [alpha-1,3-mannosyltransferase activity]
GO:0004378 [GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0033577 [protein glycosylation in endoplasmic reticulum]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051592 [response to calcium ion]
GO:0097502 [mannosylation]
Show all
 323 aa
37 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.