Tissue expression of CSF3R - Summary - The Human Protein Atlas

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CSF3R

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CSF3R
Gene description	Colony stimulating factor 3 receptor (granulocyte)
Protein class	Cancer-related genes CD markers Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, bone marrow, placenta)
GTEx:	Group enriched (lung, spleen)
FANTOM5:	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression most abundant in placenta and a subset of leukocytes.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA048086 , CAB017116
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, bone marrow, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION
Gene name	CSF3R (HGNC Symbol)
Synonyms	CD114, GCSFR
Description	Colony stimulating factor 3 receptor (granulocyte) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	36466043 - 36483278
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119535 (version 83.38)
Entrez gene	1441
UniProt	Q99062 (UniProt - Evidence at protein level)
neXtProt	NX_Q99062
Antibodypedia	CSF3R antibodies

PROTEIN BROWSER

CSF3R-001	CSF3R-003	CSF3R-004	CSF3R-018	CSF3R-019	CSF3R-201	CSF3R-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSF3R-001 ENSP00000362198 ENST00000373106	Q99062 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	836 aa 92.2 kDa	Yes	1
CSF3R-003 ENSP00000362196 ENST00000373104	Q99062 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	783 aa 86.6 kDa	Yes	1
CSF3R-004 ENSP00000362195 ENST00000373103	Q99062 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030593 [neutrophil chemotaxis] GO:0045637 [regulation of myeloid cell differentiation] GO:0097186 [amelogenesis] Show all	863 aa 95.1 kDa	Yes	1
CSF3R-018 ENSP00000435218 ENST00000464465	H0YE86 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	388 aa 42 kDa	No	1
CSF3R-019 ENSP00000431639 ENST00000533491	E9PK56 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Show all		21 aa 2.2 kDa	No	0
CSF3R-201 ENSP00000332180 ENST00000331941	Q99062 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	783 aa 86.6 kDa	Yes	1
CSF3R-202 ENSP00000355406 ENST00000361632	Q99062 [Direct mapping] Granulocyte colony-stimulating factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	836 aa 92.2 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.