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A majority of the malignant cells showed weak to moderate cytoplasmic staining with additional nuclear positivity in many cases. Several cases of liver cancer along with few cases of endometrial, colorectal, breast and prostate cancers exhibited strong immunoreactivity. Several cases of malignant lymphomas, gliomas and lung cancers were negative.
GENE INFORMATION
Gene name
DCAF4 (HGNC Symbol)
Synonyms
DKFZp434K114, WDR21, WDR21A
Description
DDB1 and CUL4 associated factor 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]