Cell atlas - PGF - The Human Protein Atlas

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PGF

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PGF
Gene description	Placental growth factor
Protein class	Cancer-related genes Candidate cardiovascular disease genes FDA approved drug targets Plasma proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & mitochondria.
RNA cell category	Group enriched (BEWO, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Mitochondria (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041624
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BEWO, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & mitochondria.

Main location

Nucleoplasm (approved)

Additional location

Mitochondria (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041624	A-431	Nucleoplasm
	HPA041624	A-431	Cytosol
	HPA041624	U-2 OS	Nucleoplasm
	HPA041624	U-2 OS	Mitochondria	Intensity
	HPA041624	U-251 MG	No staining

GENE INFORMATION
Gene name	PGF (HGNC Symbol)
Synonyms	D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760
Description	Placental growth factor (HGNC Symbol)
Entrez gene summary	This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74941834 - 74955784
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119630 (version 83.38)
Entrez gene	5228
UniProt	P49763 (UniProt - Evidence at protein level)
neXtProt	NX_P49763
Antibodypedia	PGF antibodies

PROTEIN BROWSER

PGF-001	PGF-002	PGF-003	PGF-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGF-001 ENSP00000451040 ENST00000555567	P49763 [Direct mapping] Placenta growth factor Q53XY6 [Target identity:100%; Query identity:100%] Placental growth factor; Placental growth factor, vascular endothelial growth factor-related protein; Placental growth factor, vascular endothelial growth factor-related protein, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Show all	GO:0001525 [angiogenesis] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001666 [response to hypoxia] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002040 [sprouting angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0030154 [cell differentiation] GO:0031100 [organ regeneration] GO:0032870 [cellular response to hormone stimulus] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0045766 [positive regulation of angiogenesis] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051781 [positive regulation of cell division] GO:0060688 [regulation of morphogenesis of a branching structure] Show all	170 aa 19.3 kDa	Yes	0
PGF-002 ENSP00000238607 ENST00000238607	G3XA84 [Direct mapping] Placenta growth factor Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0008083 [growth factor activity] GO:0016020 [membrane] GO:0051781 [positive regulation of cell division] Show all	169 aa 19.2 kDa	Yes	0
PGF-003 ENSP00000451413 ENST00000553716	P49763 [Direct mapping] Placenta growth factor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0030154 [cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051781 [positive regulation of cell division] Show all	149 aa 16.7 kDa	Yes	0
PGF-008 ENSP00000385365 ENST00000405431	P49763 [Direct mapping] Placenta growth factor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0030154 [cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051781 [positive regulation of cell division] Show all	221 aa 24.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.