Expression of NEK9 in cancer - Summary - The Human Protein Atlas

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NEK9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NEK9
Gene description	NIMA-related kinase 9
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA001405
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001405

GENE INFORMATION
Gene name	NEK9 (HGNC Symbol)
Synonyms	DKFZp434D0935, MGC16714, Nek8, NERCC
Description	NIMA-related kinase 9 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	75079353 - 75127344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119638 (version 83.38)
Entrez gene	91754
UniProt	Q8TD19 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD19
Antibodypedia	NEK9 antibodies

PROTEIN BROWSER

NEK9-001	NEK9-005	NEK9-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK9-001 ENSP00000238616 ENST00000238616	Q8TD19 [Direct mapping] Serine/threonine-protein kinase Nek9 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Transporters Transporter channels and pores MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0019901 [protein kinase binding] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	979 aa 107.2 kDa	No	0
NEK9-005 ENSP00000452537 ENST00000553823	G3V5V0 [Direct mapping] Serine/threonine-protein kinase Nek9 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	73 aa 8.5 kDa	No	0
NEK9-006 ENSP00000450943 ENST00000557673	G3V2Z5 [Direct mapping] Serine/threonine-protein kinase Nek9 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	128 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.