Expression of ACYP1 in cancer - Summary - The Human Protein Atlas

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ACYP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACYP1
Gene description	Acylphosphatase 1, erythrocyte (common) type
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a vast majority of tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034944
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and breast cancer (favourable).
Liver cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034944

GENE INFORMATION
Gene name	ACYP1
Synonyms
Description	Acylphosphatase 1, erythrocyte (common) type (HGNC Symbol)
Entrez gene summary	This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	75053221 - 75069483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119640 (version 83.38)
Entrez gene	97
UniProt	P07311 (UniProt - Evidence at protein level)
neXtProt	NX_P07311
Antibodypedia	ACYP1 antibodies

PROTEIN BROWSER

ACYP1-001	ACYP1-002	ACYP1-003	ACYP1-004	ACYP1-005	ACYP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACYP1-001 ENSP00000238618 ENST00000238618	P07311 [Direct mapping] Acylphosphatase-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0006796 [phosphate-containing compound metabolic process] GO:0070062 [extracellular exosome] Show all	99 aa 11.3 kDa	No	0
ACYP1-002 ENSP00000450873 ENST00000555463	G3V2U7 [Direct mapping] Acylphosphatase Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0008152 [metabolic process] Show all	129 aa 14.1 kDa	Yes	0
ACYP1-003 ENSP00000451581 ENST00000555694	P07311 [Direct mapping] Acylphosphatase-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0006796 [phosphate-containing compound metabolic process] GO:0070062 [extracellular exosome] Show all	99 aa 11.3 kDa	No	0
ACYP1-004 ENSP00000451220 ENST00000553302	G3V3F8 [Direct mapping] Acylphosphatase-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.1 kDa	No	0
ACYP1-005 ENSP00000350655 ENST00000357971	P07311 [Direct mapping] Acylphosphatase-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0006796 [phosphate-containing compound metabolic process] GO:0070062 [extracellular exosome] Show all	55 aa 6.1 kDa	No	0
ACYP1-006 ENSP00000452249 ENST00000555135	G3V597 [Direct mapping] Acylphosphatase-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.