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IFT43

GENERAL INFORMATION

Gene name

 IFT43

Gene description

 Intraflagellar transport 43

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including expression in cilia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003438
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003438

GENE INFORMATION

Gene name

 IFT43 (HGNC Symbol)

Synonyms

 C14orf179, FLJ32173, MGC16028

Description

 Intraflagellar transport 43 (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 75902136 - 76084585

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119650 (version 83.38)

Entrez gene

 112752

UniProt

 Q96FT9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96FT9

Antibodypedia

 IFT43 antibodies

PROTEIN BROWSER
IFT43-004
IFT43-005
IFT43-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFT43-004
ENSP00000238628
ENST00000238628
Q96FT9 [Direct mapping]
Intraflagellar transport protein 43 homolog
A0A024R6A9 [Target identity:100%; Query identity:100%]
HCG2028821, isoform CRA_h
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030991 [intraciliary transport particle A]
GO:0035721 [intraciliary retrograde transport]
GO:0060271 [cilium morphogenesis]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
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 213 aa
23.9 kDa 		No 0
IFT43-005
ENSP00000451096
ENST00000556742
Q96FT9 [Direct mapping]
Intraflagellar transport protein 43 homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030991 [intraciliary transport particle A]
GO:0035721 [intraciliary retrograde transport]
GO:0060271 [cilium morphogenesis]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 113 aa
12.5 kDa 		No 0
IFT43-201
ENSP00000324177
ENST00000314067
Q96FT9 [Direct mapping]
Intraflagellar transport protein 43 homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030991 [intraciliary transport particle A]
GO:0035721 [intraciliary retrograde transport]
GO:0060271 [cilium morphogenesis]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 208 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.