Expression of ACOT2 in cancer - Summary - The Human Protein Atlas

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ACOT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACOT2
Gene description	Acyl-CoA thioesterase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA043705
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043705

GENE INFORMATION
Gene name	ACOT2 (HGNC Symbol)
Synonyms	Mte1, ZAP128
Description	Acyl-CoA thioesterase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	73567620 - 73575658
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119673 (version 83.38)
Entrez gene	10965
UniProt	P49753 (UniProt - Evidence at protein level)
neXtProt	NX_P49753
Antibodypedia	ACOT2 antibodies

PROTEIN BROWSER

ACOT2-001	ACOT2-004	ACOT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACOT2-001 ENSP00000238651 ENST00000238651	P49753 [Direct mapping] Acyl-coenzyme A thioesterase 2, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000038 [very long-chain fatty acid metabolic process] GO:0001676 [long-chain fatty acid metabolic process] GO:0005102 [receptor binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006637 [acyl-CoA metabolic process] GO:0016290 [palmitoyl-CoA hydrolase activity] GO:0016790 [thiolester hydrolase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047617 [acyl-CoA hydrolase activity] GO:0052689 [carboxylic ester hydrolase activity] GO:0070062 [extracellular exosome] Show all	483 aa 53.2 kDa	No	0
ACOT2-004 ENSP00000477685 ENST00000613168	A0A087WT95 [Direct mapping] Acyl-coenzyme A thioesterase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006637 [acyl-CoA metabolic process] GO:0016790 [thiolester hydrolase activity] Show all	463 aa 50.9 kDa	No	0
ACOT2-201 ENSP00000483704 ENST00000622407	A0A087X0W7 [Direct mapping] Acyl-coenzyme A thioesterase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006637 [acyl-CoA metabolic process] GO:0016790 [thiolester hydrolase activity] Show all	421 aa 46.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.