Expression of FLVCR2 in cancer - Summary - The Human Protein Atlas

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FLVCR2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FLVCR2
Gene description	Feline leukemia virus subgroup C cellular receptor family, member 2
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BEWO)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA037984
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037984

GENE INFORMATION
Gene name	FLVCR2 (HGNC Symbol)
Synonyms	C14orf58, FLJ20371, MFSD7C
Description	Feline leukemia virus subgroup C cellular receptor family, member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	75578617 - 75663214
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119686 (version 83.38)
Entrez gene	55640
UniProt	Q9UPI3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPI3
Antibodypedia	FLVCR2 antibodies

PROTEIN BROWSER

FLVCR2-001	FLVCR2-002	FLVCR2-004	FLVCR2-006	FLVCR2-010	FLVCR2-011	FLVCR2-012	FLVCR2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLVCR2-001 ENSP00000238667 ENST00000238667	Q9UPI3 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0015232 [heme transporter activity] GO:0015886 [heme transport] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0055085 [transmembrane transport] Show all	526 aa 57.2 kDa	No	>9
FLVCR2-002 ENSP00000443439 ENST00000539311	Q9UPI3 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0015232 [heme transporter activity] GO:0015886 [heme transport] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0055085 [transmembrane transport] Show all	321 aa 35.3 kDa	No	7
FLVCR2-004 ENSP00000451781 ENST00000554580	G3V4G2 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	203 aa 22.1 kDa	No	6
FLVCR2-006 ENSP00000451104 ENST00000555058	G3V391 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	88 aa 9.8 kDa	No	1
FLVCR2-010 ENSP00000451603 ENST00000553587	G3V458 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	133 aa 14.7 kDa	No	2
FLVCR2-011 ENSP00000452468 ENST00000556856	G3V5Q8 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.3 kDa	No	0
FLVCR2-012 ENSP00000452584 ENST00000553341	G3V5Y3 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	203 aa 22.2 kDa	No	7
FLVCR2-013 ENSP00000452453 ENST00000555027	G3V5P5 [Direct mapping] Feline leukemia virus subgroup C receptor-related protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	241 aa 26.3 kDa	No	6

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The Human Protein Atlas

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