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DLST

GENERAL INFORMATION

Gene name

 DLST

Gene description

 Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

Protein class

 Citric acid cycle related proteins
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous granular cytoplasmic expression in a majority of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA003010
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003010

GENE INFORMATION

Gene name

 DLST (HGNC Symbol)

Synonyms

 DLTS

Description

 Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 74881891 - 74903745

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119689 (version 83.38)

Entrez gene

 1743

UniProt

 P36957 (UniProt - Evidence at protein level)

neXtProt

 NX_P36957

Antibodypedia

 DLST antibodies

PROTEIN BROWSER
DLST-001
DLST-006
DLST-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLST-001
ENSP00000335304
ENST00000334220
P36957 [Direct mapping]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
A0A024R6C9 [Target identity:100%; Query identity:100%]
Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004149 [dihydrolipoyllysine-residue succinyltransferase activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006099 [tricarboxylic acid cycle]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006734 [NADH metabolic process]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031072 [heat shock protein binding]
GO:0033512 [L-lysine catabolic process to acetyl-CoA via saccharopine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043209 [myelin sheath]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0051087 [chaperone binding]
GO:0070062 [extracellular exosome]
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 453 aa
48.8 kDa 		No 0
DLST-006
ENSP00000451957
ENST00000554806
Q86SW4 [Direct mapping]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; Full-length cDNA 5-PRIME end of clone CS0DJ009YL13 of T cells (Jurkat cell line) of Homo sapiens (human)
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
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 279 aa
29.6 kDa 		No 0
DLST-201
ENSP00000487251
ENST00000626051
G3V5M3 [Direct mapping]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.