Fields »
ABOUT
HELP
BLOG
EIF2B2

GENERAL INFORMATION

Gene name

 EIF2B2

Gene description

 Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA005841 , HPA048028 , CAB037105
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005841
HPA048028
CAB037105

GENE INFORMATION

Gene name

 EIF2B2 (HGNC Symbol)

Synonyms

 EIF-2Bbeta, EIF2B

Description

 Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 75002911 - 75012366

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119718 (version 83.38)

Entrez gene

 8892

UniProt

 P49770 (UniProt - Evidence at protein level)

neXtProt

 NX_P49770

Antibodypedia

 EIF2B2 antibodies

PROTEIN BROWSER
EIF2B2-001
EIF2B2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2B2-001
ENSP00000266126
ENST00000266126
P49770 [Direct mapping]
Translation initiation factor eIF-2B subunit beta
Q53XC2 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Full-length cDNA clone CS0DI071YM04 of Placenta of Homo sapiens (human)
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0007417 [central nervous system development]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014003 [oligodendrocyte development]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044237 [cellular metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0051716 [cellular response to stimulus]
Show all
 351 aa
39 kDa 		No 0
EIF2B2-006
ENSP00000452582
ENST00000554748
H0YK01 [Direct mapping]
Translation initiation factor eIF-2B subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0044237 [cellular metabolic process]
Show all
 71 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.