Cell atlas - ATAD2B - The Human Protein Atlas

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ATAD2B

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ATAD2B
Gene description	ATPase family, AAA domain containing 2B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA034555
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034555	A-431	Nucleoplasm
	HPA034555	U-2 OS	Nucleoplasm
	HPA034555	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	ATAD2B (HGNC Symbol)
Synonyms	KIAA1240
Description	ATPase family, AAA domain containing 2B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	2
Cytoband
Chromosome location (bp)	23748664 - 23927114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119778 (version 83.38)
Entrez gene	54454
UniProt	Q9ULI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULI0
Antibodypedia	ATAD2B antibodies

PROTEIN BROWSER

ATAD2B-001	ATAD2B-002	ATAD2B-004	ATAD2B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATAD2B-001 ENSP00000238789 ENST00000238789	Q9ULI0 [Direct mapping] ATPase family AAA domain-containing protein 2B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0016887 [ATPase activity] GO:0031936 [negative regulation of chromatin silencing] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070577 [lysine-acetylated histone binding] Show all	1458 aa 164.9 kDa	No	0
ATAD2B-002 ENSP00000403177 ENST00000439915	C9JG15 [Direct mapping] ATPase family AAA domain-containing protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0016887 [ATPase activity] GO:0031936 [negative regulation of chromatin silencing] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	370 aa 41.2 kDa	No	0
ATAD2B-004 ENSP00000370412 ENST00000381024	H7BYF1 [Direct mapping] ATPase family AAA domain-containing protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0016887 [ATPase activity] GO:0031936 [negative regulation of chromatin silencing] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	734 aa 83.9 kDa	No	0
ATAD2B-006 ENSP00000392764 ENST00000458510	C9J1G9 [Direct mapping] ATPase family AAA domain-containing protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0016887 [ATPase activity] GO:0031936 [negative regulation of chromatin silencing] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	64 aa 7.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.