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GENERAL INFORMATION

Gene name

 IDE

Gene description

 Insulin-degrading enzyme

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues, few with additional membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA063478
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and colorectal cancer (favourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063478

GENE INFORMATION

Gene name

 IDE

Synonyms

Description

 Insulin-degrading enzyme (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q23.33

Chromosome location (bp)

 92451684 - 92574076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119912 (version 83.38)

Entrez gene

 3416

UniProt

 P14735 (UniProt - Evidence at protein level)

neXtProt

 NX_P14735

Antibodypedia

 IDE antibodies

PROTEIN BROWSER
IDE-001
IDE-007
IDE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IDE-001
ENSP00000265986
ENST00000265986
P14735 [Direct mapping]
Insulin-degrading enzyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0001618 [virus receptor activity]
GO:0001948 [glycoprotein binding]
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008340 [determination of adult lifespan]
GO:0009986 [cell surface]
GO:0010815 [bradykinin catabolic process]
GO:0010992 [ubiquitin homeostasis]
GO:0016485 [protein processing]
GO:0016887 [ATPase activity]
GO:0017046 [peptide hormone binding]
GO:0031597 [cytosolic proteasome complex]
GO:0031626 [beta-endorphin binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042277 [peptide binding]
GO:0042447 [hormone catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043559 [insulin binding]
GO:0044257 [cellular protein catabolic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0050435 [beta-amyloid metabolic process]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0051291 [protein heterooligomerization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:1901142 [insulin metabolic process]
GO:1901143 [insulin catabolic process]
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 1019 aa
118 kDa 		Yes 0
IDE-007
ENSP00000408850
ENST00000436178
Q5T5N3 [Direct mapping]
Insulin-degrading enzyme
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
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 257 aa
29.2 kDa 		No 0
IDE-201
ENSP00000360637
ENST00000371581
P14735 [Direct mapping]
Insulin-degrading enzyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001948 [glycoprotein binding]
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008340 [determination of adult lifespan]
GO:0009986 [cell surface]
GO:0010815 [bradykinin catabolic process]
GO:0010992 [ubiquitin homeostasis]
GO:0016485 [protein processing]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042277 [peptide binding]
GO:0042447 [hormone catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043559 [insulin binding]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0050435 [beta-amyloid metabolic process]
GO:0051260 [protein homooligomerization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:1901142 [insulin metabolic process]
GO:1901143 [insulin catabolic process]
Show all
 464 aa
54.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.