Fields »
ABOUT
HELP
BLOG
ELOVL3

GENERAL INFORMATION

Gene name

 ELOVL3

Gene description

 ELOVL fatty acid elongase 3

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (SiHa)
HPA (normal tissue):Tissue enhanced (adipose tissue, breast, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly expressed in sebaceous glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA036236
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA036236

GENE INFORMATION

Gene name

 ELOVL3 (HGNC Symbol)

Synonyms

 CIG-30

Description

 ELOVL fatty acid elongase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102226328 - 102229589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119915 (version 83.38)

Entrez gene

 83401

UniProt

 Q9HB03 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HB03

Antibodypedia

 ELOVL3 antibodies

PROTEIN BROWSER
ELOVL3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELOVL3-001
ENSP00000359022
ENST00000370005
Q9HB03 [Direct mapping]
Elongation of very long chain fatty acids protein 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006636 [unsaturated fatty acid biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
GO:0019367 [fatty acid elongation, saturated fatty acid]
GO:0019432 [triglyceride biosynthetic process]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0034626 [fatty acid elongation, polyunsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 270 aa
31.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.