Expression of MXI1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MXI1

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MXI1
Gene description	MAX interactor 1, dimerization protein
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA035319
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and prostate cancer (unfavourable).
Renal cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035319

GENE INFORMATION
Gene name	MXI1 (HGNC Symbol)
Synonyms	bHLHc11, MAD2, MXD2, MXI
Description	MAX interactor 1, dimerization protein (HGNC Symbol)
Entrez gene summary	Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q25.2
Chromosome location (bp)	110207605 - 110287365
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119950 (version 83.38)
Entrez gene	4601
UniProt	P50539 (UniProt - Evidence at protein level)
neXtProt	NX_P50539
Antibodypedia	MXI1 antibodies

PROTEIN BROWSER

MXI1-004	MXI1-005	MXI1-006	MXI1-008	MXI1-009	MXI1-010	MXI1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MXI1-004 ENSP00000331152 ENST00000332674	P50539 [Direct mapping] Max-interacting protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0046983 [protein dimerization activity] Show all	295 aa 32.8 kDa	No	0
MXI1-005 ENSP00000354606 ENST00000361248	P50539 [Direct mapping] Max-interacting protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0046983 [protein dimerization activity] Show all	182 aa 20.6 kDa	No	0
MXI1-006 ENSP00000239007 ENST00000239007	P50539 [Direct mapping] Max-interacting protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0046983 [protein dimerization activity] Show all	228 aa 26.1 kDa	No	0
MXI1-008 ENSP00000398981 ENST00000453116	F6U3F6 [Direct mapping] Max-interacting protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0046983 [protein dimerization activity] Show all	226 aa 25.3 kDa	No	0
MXI1-009 ENSP00000376842 ENST00000393134	B1ANN8 [Direct mapping] Max-interacting protein 1; cDNA FLJ61042, highly similar to MAX-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0046983 [protein dimerization activity] Show all	218 aa 24.9 kDa	No	0
MXI1-010 ENSP00000407711 ENST00000442296	F6WCI9 [Direct mapping] Max-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	118 aa 13.8 kDa	No	0
MXI1-011 ENSP00000358625 ENST00000369612	P50539 [Direct mapping] Max-interacting protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0046983 [protein dimerization activity] Show all	192 aa 21.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.