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PRLHR

GENERAL INFORMATION

Gene name

 PRLHR

Gene description

 Prolactin releasing hormone receptor

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, cerebral cortex, endometrium, smooth muscle)
GTEx:Tissue enhanced (pituitary gland, vagina)
FANTOM5:Group enriched (cerebellum, cervix, uterine, endometrium, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in subsets of cells in anterior pituitary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039361
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Pituitary gland

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebral cortex, endometrium, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, cervix, uterine, endometrium, pituitary gland)

GENE INFORMATION

Gene name

 PRLHR (HGNC Symbol)

Synonyms

 GPR10, PrRPR

Description

 Prolactin releasing hormone receptor (HGNC Symbol)

Entrez gene summary

 PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q26.11

Chromosome location (bp)

 118589989 - 118595699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119973 (version 83.38)

Entrez gene

 2834

UniProt

 P49683 (UniProt - Evidence at protein level)

neXtProt

 NX_P49683

Antibodypedia

 PRLHR antibodies

PROTEIN BROWSER
PRLHR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRLHR-001
ENSP00000239032
ENST00000239032
P49683 [Direct mapping]
Prolactin-releasing peptide receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004983 [neuropeptide Y receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007565 [female pregnancy]
GO:0007631 [feeding behavior]
GO:0008188 [neuropeptide receptor activity]
GO:0016021 [integral component of membrane]
GO:0042445 [hormone metabolic process]
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 370 aa
41.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.