Expression of WDR11 in cancer - Summary - The Human Protein Atlas

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WDR11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WDR11
Gene description	WD repeat domain 11
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038980
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038980

GENE INFORMATION
Gene name	WDR11 (HGNC Symbol)
Synonyms	BRWD2, DR11, FLJ10506, HH14, KIAA1351, WDR15
Description	WD repeat domain 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.12
Chromosome location (bp)	120851175 - 120909524
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120008 (version 83.38)
Entrez gene	55717
UniProt	Q9BZH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZH6
Antibodypedia	WDR11 antibodies

PROTEIN BROWSER

WDR11-001	WDR11-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR11-001 ENSP00000263461 ENST00000263461	Q9BZH6 [Direct mapping] WD repeat-containing protein 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005929 [cilium] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1224 aa 136.7 kDa	No	1
WDR11-016 ENSP00000474880 ENST00000604585	S4R3Z0 [Direct mapping] WD repeat-containing protein 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0015630 [microtubule cytoskeleton] Show all	312 aa 34.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.