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KCNIP2

GENERAL INFORMATION

Gene name

 KCNIP2

Gene description

 Kv channel interacting protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Group enriched (adipose tissue, cerebral cortex, heart muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed
0.05.01015202530FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KCNIP2 (HGNC Symbol)

Synonyms

 KCHIP2

Description

 Kv channel interacting protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 101825974 - 101843920

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120049 (version 83.38)

Entrez gene

 30819

UniProt

 Q9NS61 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NS61

Antibodypedia

 KCNIP2 antibodies

PROTEIN BROWSER
KCNIP2-001
KCNIP2-002
KCNIP2-003
KCNIP2-006
KCNIP2-009
KCNIP2-010
KCNIP2-013
KCNIP2-014
KCNIP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNIP2-001
ENSP00000341624
ENST00000353068
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 227 aa
26.3 kDa 		No 0
KCNIP2-002
ENSP00000239117
ENST00000239117
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 184 aa
21.4 kDa 		No 0
KCNIP2-003
ENSP00000411679
ENST00000434163
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 177 aa
20.5 kDa 		No 0
KCNIP2-006
ENSP00000359063
ENST00000370046
A6NFF4 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
Show all
 184 aa
21.5 kDa 		No 0
KCNIP2-009
ENSP00000349055
ENST00000356640
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 270 aa
30.9 kDa 		No 0
KCNIP2-010
ENSP00000239118
ENST00000348850
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 225 aa
26.1 kDa 		No 0
KCNIP2-013
ENSP00000420040
ENST00000461105
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 285 aa
32.5 kDa 		No 0
KCNIP2-014
ENSP00000344169
ENST00000343195
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 220 aa
25.6 kDa 		No 0
KCNIP2-201
ENSP00000350733
ENST00000358038
Q9NS61 [Direct mapping]
Kv channel-interacting protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006813 [potassium ion transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0046923 [ER retention sequence binding]
GO:0047485 [protein N-terminus binding]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086009 [membrane repolarization]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:2001257 [regulation of cation channel activity]
Show all
 252 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.