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HOXB5

GENERAL INFORMATION

Gene name

 HOXB5

Gene description

 Homeobox B5

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Cell line enhanced (HEK93, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (epididymis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), lung cancer (unfavourable) and endometrial cancer (favourable).
Urothelial cancer p<0.001
Lung cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HOXB5 (HGNC Symbol)

Synonyms

 HOX2, HOX2A

Description

 Homeobox B5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48591257 - 48593961

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120075 (version 83.38)

Entrez gene

 3215

UniProt

 P09067 (UniProt - Evidence at protein level)

neXtProt

 NX_P09067

Antibodypedia

 HOXB5 antibodies

PROTEIN BROWSER
HOXB5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB5-001
ENSP00000239151
ENST00000239151
P09067 [Direct mapping]
Homeobox protein Hox-B5
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0043565 [sequence-specific DNA binding]
GO:0045446 [endothelial cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048706 [embryonic skeletal system development]
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 269 aa
29.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.