Expression of CRHR1 in cancer - Summary - The Human Protein Atlas

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CRHR1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CRHR1
Gene description	Corticotropin releasing hormone receptor 1
Protein class	G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RT4, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CRHR1 (HGNC Symbol)
Synonyms	CRF-R, CRF1, CRHR
Description	Corticotropin releasing hormone receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	45784280 - 45835828
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120088 (version 83.38)
Entrez gene	1394
UniProt	P34998 (UniProt - Evidence at protein level)
neXtProt	NX_P34998
Antibodypedia	CRHR1 antibodies

PROTEIN BROWSER

CRHR1-001	CRHR1-002	CRHR1-003	CRHR1-004	CRHR1-009	CRHR1-201	CRHR1-202	CRHR1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRHR1-001 ENSP00000381333 ENST00000398285	P34998 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007565 [female pregnancy] GO:0007567 [parturition] GO:0010578 [regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0015056 [corticotrophin-releasing factor receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0051458 [corticotropin secretion] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:1901386 [negative regulation of voltage-gated calcium channel activity] GO:2000852 [regulation of corticosterone secretion] Show all	444 aa 50.7 kDa	Yes	7
CRHR1-002 ENSP00000326060 ENST00000314537	P34998 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007565 [female pregnancy] GO:0007567 [parturition] GO:0010578 [regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0015056 [corticotrophin-releasing factor receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0051458 [corticotropin secretion] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:1901386 [negative regulation of voltage-gated calcium channel activity] GO:2000852 [regulation of corticosterone secretion] Show all	415 aa 47.7 kDa	Yes	7
CRHR1-003 ENSP00000344068 ENST00000352855	P34998 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007565 [female pregnancy] GO:0007567 [parturition] GO:0010578 [regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0015056 [corticotrophin-releasing factor receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0051458 [corticotropin secretion] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:1901386 [negative regulation of voltage-gated calcium channel activity] GO:2000852 [regulation of corticosterone secretion] Show all	375 aa 43.3 kDa	Yes	7
CRHR1-004 ENSP00000462016 ENST00000577353	P34998 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007565 [female pregnancy] GO:0007567 [parturition] GO:0010578 [regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0015056 [corticotrophin-releasing factor receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0051458 [corticotropin secretion] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:1901386 [negative regulation of voltage-gated calcium channel activity] GO:2000852 [regulation of corticosterone secretion] Show all	401 aa 46 kDa	Yes	7
CRHR1-009 ENSP00000463177 ENST00000580876	J3QKP8 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	75 aa 8.4 kDa	No	1
CRHR1-201 ENSP00000293493 ENST00000293493	A0A0A0MQZ1 [Direct mapping] Corticotropin-releasing factor receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	430 aa 49.1 kDa	Yes	7
CRHR1-202 ENSP00000340522 ENST00000339069	B3TIK8 [Direct mapping] CRF1 receptor isoform I variant B; Corticotropin-releasing factor receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	314 aa 36.6 kDa	No	7
CRHR1-203 ENSP00000484545 ENST00000619154	K9J956 [Direct mapping] CRH receptor 1 variant B; Corticotropin-releasing factor receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] Show all	154 aa 16.7 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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