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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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DUSP1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DUSP1

Gene description

Dual specificity phosphatase 1

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
CAB018554
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PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB018554

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers displayed moderate cytoplasmic positivity. A few cases of squamous cell carcinomas of cervix and renal adenocarcinomas showed strong cytoplasmic immunoreactivity. Most lymphomas and skin cancers were negative while many cases of melanoma, breast, prostate and urothelial cancers were weakly stained.

GENE INFORMATION

Gene name

DUSP1 (HGNC Symbol)

Synonyms

CL100, HVH1, MKP-1, PTPN10

Description

Dual specificity phosphatase 1 (HGNC Symbol)

Entrez gene summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

172768090 - 172771195

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120129 (version 83.38)

Entrez gene

1843

UniProt

P28562 (UniProt - Evidence at protein level)

neXtProt

NX_P28562

Antibodypedia

DUSP1 antibodies

PROTEIN BROWSER

DUSP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP1-001
ENSP00000239223
ENST00000239223
P28562 [Direct mapping]
Dual specificity protein phosphatase 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000188 [inactivation of MAPK activity]
GO:0001706 [endoderm formation]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0006979 [response to oxidative stress]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008330 [protein tyrosine/threonine phosphatase activity]
GO:0009416 [response to light stimulus]
GO:0010033 [response to organic substance]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0019838 [growth factor binding]
GO:0032355 [response to estradiol]
GO:0032526 [response to retinoic acid]
GO:0032870 [cellular response to hormone stimulus]
GO:0033574 [response to testosterone]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0042542 [response to hydrogen peroxide]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0051384 [response to glucocorticoid]
GO:0051447 [negative regulation of meiotic cell cycle]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071850 [mitotic cell cycle arrest]
GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint]
GO:2000279 [negative regulation of DNA biosynthetic process]
Show all
367 aa
39.3 kDa
No 0

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