We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most thyroid cancers as well as a few cases of lung, urothelial, gastric and liver cancers showed distinct nuclear immunoreactivity. Remaining cancer cells in general were weakly stained or negative.
GENE INFORMATION
Gene name
MSX2 (HGNC Symbol)
Synonyms
CRS2, FPP, HOX8, MSH, PFM, PFM1
Description
Msh homeobox 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001503 [ossification] GO:0001649 [osteoblast differentiation] GO:0002063 [chondrocyte development] GO:0002076 [osteoblast development] GO:0003148 [outflow tract septum morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation] GO:0003416 [endochondral bone growth] GO:0003677 [DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0009952 [anterior/posterior pattern specification] GO:0010942 [positive regulation of cell death] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030326 [embryonic limb morphogenesis] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032792 [negative regulation of CREB transcription factor activity] GO:0035115 [embryonic forelimb morphogenesis] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035313 [wound healing, spreading of epidermal cells] GO:0035880 [embryonic nail plate morphogenesis] GO:0042060 [wound healing] GO:0042476 [odontogenesis] GO:0042733 [embryonic digit morphogenesis] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045599 [negative regulation of fat cell differentiation] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048863 [stem cell differentiation] GO:0051216 [cartilage development] GO:0051795 [positive regulation of catagen] GO:0060346 [bone trabecula formation] GO:0060349 [bone morphogenesis] GO:0060363 [cranial suture morphogenesis] GO:0060364 [frontal suture morphogenesis] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0061180 [mammary gland epithelium development] GO:0061312 [BMP signaling pathway involved in heart development] GO:0070166 [enamel mineralization] GO:0071363 [cellular response to growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0090427 [activation of meiosis] GO:2000678 [negative regulation of transcription regulatory region DNA binding] GO:2001055 [positive regulation of mesenchymal cell apoptotic process]