Expression of CAAP1 in cancer - Summary - The Human Protein Atlas

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CAAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAAP1
Gene description	Caspase activity and apoptosis inhibitor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA020404 , HPA024029 , HPA024100
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020404	HPA024029	HPA024100

GENE INFORMATION
Gene name	CAAP1 (HGNC Symbol)
Synonyms	C9orf82, CAAP, FLJ13657
Description	Caspase activity and apoptosis inhibitor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p21.2
Chromosome location (bp)	26840685 - 26892804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120159 (version 83.38)
Entrez gene	79886
UniProt	Q9H8G2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8G2
Antibodypedia	CAAP1 antibodies

PROTEIN BROWSER

CAAP1-001	CAAP1-005	CAAP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAAP1-001 ENSP00000369431 ENST00000333916	Q9H8G2 [Direct mapping] Caspase activity and apoptosis inhibitor 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] Show all	361 aa 38.4 kDa	No	0
CAAP1-005 ENSP00000427938 ENST00000520187	E5RFV1 [Direct mapping] Caspase activity and apoptosis inhibitor 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11 kDa	No	0
CAAP1-006 ENSP00000487373 ENST00000625311	Q9H8G2 [Direct mapping] Caspase activity and apoptosis inhibitor 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] Show all	216 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.