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INSL6

GENERAL INFORMATION

Gene name

 INSL6

Gene description

 Insulin-like 6

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in spermatid acrosomes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA021364
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021364

GENE INFORMATION

Gene name

 INSL6 (HGNC Symbol)

Synonyms

 RIF1

Description

 Insulin-like 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 5131979 - 5185668

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120210 (version 83.38)

Entrez gene

 11172

UniProt

 Q9Y581 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y581

Antibodypedia

 INSL6 antibodies

PROTEIN BROWSER
INSL6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INSL6-001
ENSP00000371054
ENST00000381641
Q9Y581 [Direct mapping]
Insulin-like peptide INSL6 Insulin-like peptide INSL6 B chain Insulin-like peptide INSL6 A chain
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0005179 [hormone activity]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0008150 [biological_process]
GO:0008584 [male gonad development]
GO:0009566 [fertilization]
GO:0030317 [sperm motility]
GO:0043066 [negative regulation of apoptotic process]
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 213 aa
24.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.