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INSL4

GENERAL INFORMATION

Gene name

 INSL4

Gene description

 Insulin-like 4 (placenta)

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (lung cancer)
HPA (cell line):Cell line enriched (A549)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (lung cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 INSL4 (HGNC Symbol)

Synonyms

 EPIL

Description

 Insulin-like 4 (placenta) (HGNC Symbol)

Entrez gene summary

 INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 5231419 - 5235304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120211 (version 83.38)

Entrez gene

 3641

UniProt

 Q14641 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14641

Antibodypedia

 INSL4 antibodies

PROTEIN BROWSER
INSL4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INSL4-001
ENSP00000239316
ENST00000239316
Q14641 [Direct mapping]
Early placenta insulin-like peptide Early placenta insulin-like peptide B chain Early placenta insulin-like peptide A chain
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005102 [receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0007565 [female pregnancy]
GO:0008283 [cell proliferation]
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 139 aa
15.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.