Cell atlas - MRPS14 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MRPS14
Gene description	Mitochondrial ribosomal protein S14
Protein class	Predicted secreted proteins Ribosomal proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane & mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (supported), Mitochondria (supported)
Mouse	Localized to the Nuclear membrane, Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA051087
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane & mitochondria.

Main location

Nuclear membrane (supported), Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA051087	A-431	Nuclear membrane
HPA051087	A-431	Mitochondria
HPA051087	HEK 293	Nuclear membrane
HPA051087	HEK 293	Mitochondria
HPA051087	U-2 OS	Nuclear membrane
HPA051087	U-2 OS	Mitochondria

MOUSE CELLS

Main location

Nuclear membrane, Mitochondria

Mouse gene

ENSMUSG00000058267 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051087	NIH 3T3	Nuclear membrane
	HPA051087	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	MRPS14 (HGNC Symbol)
Synonyms	HSMRPS14
Description	Mitochondrial ribosomal protein S14 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	175010789 - 175023425
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120333 (version 83.38)
Entrez gene	63931
UniProt	O60783 (UniProt - Evidence at protein level)
neXtProt	NX_O60783
Antibodypedia	MRPS14 antibodies

PROTEIN BROWSER

MRPS14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS14-001 ENSP00000420714 ENST00000476371	O60783 [Direct mapping] 28S ribosomal protein S14, mitochondrial Show all	Ribosomal proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005763 [mitochondrial small ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	128 aa 15.1 kDa	Yes	0