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ENY2

GENERAL INFORMATION

Gene name

 ENY2

Gene description

 Enhancer of yellow 2 homolog (Drosophila)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA024648
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024648

GENE INFORMATION

Gene name

 ENY2 (HGNC Symbol)

Synonyms

 DC6, FLJ20480, Sus1

Description

 Enhancer of yellow 2 homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q23.1

Chromosome location (bp)

 109334324 - 109345953

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120533 (version 83.38)

Entrez gene

 56943

UniProt

 Q9NPA8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPA8

Antibodypedia

 ENY2 antibodies

PROTEIN BROWSER
ENY2-001
ENY2-003
ENY2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENY2-001
ENSP00000429986
ENST00000521688
Q9NPA8 [Direct mapping]
Transcription and mRNA export factor ENY2
A0A024R9D9 [Target identity:100%; Query identity:100%]
Transcription and mRNA export factor ENY2
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124 [SAGA complex]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005643 [nuclear pore]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0015031 [protein transport]
GO:0016578 [histone deubiquitination]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070390 [transcription export complex 2]
GO:0071819 [DUBm complex]
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 101 aa
11.5 kDa 		No 0
ENY2-003
ENSP00000429713
ENST00000521662
Q9NPA8 [Direct mapping]
Transcription and mRNA export factor ENY2
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124 [SAGA complex]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005643 [nuclear pore]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0015031 [protein transport]
GO:0016578 [histone deubiquitination]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070390 [transcription export complex 2]
GO:0071819 [DUBm complex]
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 96 aa
11 kDa 		No 0
ENY2-012
ENSP00000429588
ENST00000520147
E5RHX8 [Direct mapping]
Transcription and mRNA export factor ENY2
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124 [SAGA complex]
GO:0005643 [nuclear pore]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006406 [mRNA export from nucleus]
GO:0015031 [protein transport]
GO:0016578 [histone deubiquitination]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070390 [transcription export complex 2]
GO:0071819 [DUBm complex]
Show all
 100 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.