Expression of CCDC77 in cancer - Summary - The Human Protein Atlas

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CCDC77

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC77
Gene description	Coiled-coil domain containing 77
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and/or cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038854
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038854

GENE INFORMATION
Gene name	CCDC77 (HGNC Symbol)
Synonyms	MGC13183
Description	Coiled-coil domain containing 77 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	389273 - 442645
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120647 (version 83.38)
Entrez gene	84318
UniProt	Q9BR77 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BR77
Antibodypedia	CCDC77 antibodies

PROTEIN BROWSER

CCDC77-001	CCDC77-002	CCDC77-003	CCDC77-004	CCDC77-006	CCDC77-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC77-001 ENSP00000239830 ENST00000239830	Q9BR77 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0016020 [membrane] Show all	488 aa 57.5 kDa	No	0
CCDC77-002 ENSP00000445873 ENST00000543504	F5H0W5 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		386 aa 45.9 kDa	No	0
CCDC77-003 ENSP00000412925 ENST00000412006	Q9BR77 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0016020 [membrane] Show all	456 aa 54 kDa	No	0
CCDC77-004 ENSP00000440554 ENST00000540180	Q9BR77 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0016020 [membrane] Show all	456 aa 54 kDa	No	0
CCDC77-006 ENSP00000443209 ENST00000535052	F5H5Q8 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.5 kDa	No	0
CCDC77-201 ENSP00000391870 ENST00000422000	Q9BR77 [Direct mapping] Coiled-coil domain-containing protein 77 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0016020 [membrane] Show all	456 aa 54 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.