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TAF12

GENERAL INFORMATION

Gene name

 TAF12

Gene description

 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA008519
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008519

GENE INFORMATION

Gene name

 TAF12 (HGNC Symbol)

Synonyms

 TAF2J, TAFII20

Description

 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa (HGNC Symbol)

Entrez gene summary

 Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 28589323 - 28643085

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120656 (version 83.38)

Entrez gene

 6883

UniProt

 Q16514 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16514

Antibodypedia

 TAF12 antibodies

PROTEIN BROWSER
TAF12-001
TAF12-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF12-001
ENSP00000263974
ENST00000263974
Q16514 [Direct mapping]
Transcription initiation factor TFIID subunit 12
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000125 [PCAF complex]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006325 [chromatin organization]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1903506 [regulation of nucleic acid-templated transcription]
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 161 aa
17.9 kDa 		No 0
TAF12-002
ENSP00000362930
ENST00000373824
Q16514 [Direct mapping]
Transcription initiation factor TFIID subunit 12
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000125 [PCAF complex]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006325 [chromatin organization]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
 161 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.