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SMAD9

GENERAL INFORMATION

Gene name

 SMAD9

Gene description

 SMAD family member 9

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA031162 , CAB009119
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and thyroid cancer (unfavourable).
Glioma p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031162
CAB009119

GENE INFORMATION

Gene name

 SMAD9 (HGNC Symbol)

Synonyms

 MADH6, MADH9

Description

 SMAD family member 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 36844831 - 36920765

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120693 (version 83.38)

Entrez gene

 4093

UniProt

 O15198 (UniProt - Evidence at protein level)

neXtProt

 NX_O15198

Antibodypedia

 SMAD9 antibodies

PROTEIN BROWSER
SMAD9-001
SMAD9-002
SMAD9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMAD9-001
ENSP00000239885
ENST00000350148
O15198 [Direct mapping]
Mothers against decapentaplegic homolog 9
A0A024RDR3 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
GO:0060395 [SMAD protein signal transduction]
GO:0071141 [SMAD protein complex]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
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 430 aa
48.6 kDa 		No 0
SMAD9-002
ENSP00000382216
ENST00000399275
O15198 [Direct mapping]
Mothers against decapentaplegic homolog 9
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
GO:0060395 [SMAD protein signal transduction]
GO:0071141 [SMAD protein complex]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
 467 aa
52.5 kDa 		No 0
SMAD9-201
ENSP00000369154
ENST00000379826
O15198 [Direct mapping]
Mothers against decapentaplegic homolog 9
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001657 [ureteric bud development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060348 [bone development]
GO:0060395 [SMAD protein signal transduction]
GO:0071141 [SMAD protein complex]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
 467 aa
52.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.