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ETF1

GENERAL INFORMATION

Gene name

 ETF1

Gene description

 Eukaryotic translation termination factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA037511 , CAB011686
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable), thyroid cancer (unfavourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001
Thyroid cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037511
CAB011686

GENE INFORMATION

Gene name

 ETF1 (HGNC Symbol)

Synonyms

 ERF, ERF1, RF1, SUP45L1, TB3-1

Description

 Eukaryotic translation termination factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138506095 - 138543300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120705 (version 83.38)

Entrez gene

 2107

UniProt

 P62495 (UniProt - Evidence at protein level)

neXtProt

 NX_P62495

Antibodypedia

 ETF1 antibodies

PROTEIN BROWSER
ETF1-001
ETF1-002
ETF1-003
ETF1-006
ETF1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ETF1-001
ENSP00000353741
ENST00000360541
P62495 [Direct mapping]
Eukaryotic peptide chain release factor subunit 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003747 [translation release factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006415 [translational termination]
GO:0006449 [regulation of translational termination]
GO:0006479 [protein methylation]
GO:0008079 [translation termination factor activity]
GO:0010467 [gene expression]
GO:0016149 [translation release factor activity, codon specific]
GO:0018444 [translation release factor complex]
GO:0043022 [ribosome binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 437 aa
49 kDa 		No 0
ETF1-002
ENSP00000421288
ENST00000499810
P62495 [Direct mapping]
Eukaryotic peptide chain release factor subunit 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003747 [translation release factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006415 [translational termination]
GO:0006449 [regulation of translational termination]
GO:0006479 [protein methylation]
GO:0008079 [translation termination factor activity]
GO:0010467 [gene expression]
GO:0016149 [translation release factor activity, codon specific]
GO:0018444 [translation release factor complex]
GO:0043022 [ribosome binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 404 aa
45.5 kDa 		No 0
ETF1-003
ENSP00000422203
ENST00000503014
B7Z7P8 [Direct mapping]
Eukaryotic peptide chain release factor subunit 1; cDNA FLJ56175, highly similar to Eukaryotic peptide chain release factor subunit1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006415 [translational termination]
GO:0016149 [translation release factor activity, codon specific]
GO:0018444 [translation release factor complex]
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 423 aa
47.5 kDa 		No 0
ETF1-006
ENSP00000425689
ENST00000507939
D6RJE8 [Direct mapping]
Eukaryotic peptide chain release factor subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005829 [cytosol]
GO:0006415 [translational termination]
GO:0016149 [translation release factor activity, codon specific]
GO:0018444 [translation release factor complex]
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 120 aa
13.3 kDa 		No 0
ETF1-009
ENSP00000461082
ENST00000572514
I3L492 [Direct mapping]
Eukaryotic peptide chain release factor subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006415 [translational termination]
GO:0016149 [translation release factor activity, codon specific]
GO:0018444 [translation release factor complex]
Show all
 208 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.