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Cancer tissues showed moderate to strong cytoplasmic immunoreactivity. Most cases of gliomas and lymphomas were negative.
GENE INFORMATION
Gene name
SIL1 (HGNC Symbol)
Synonyms
BAP, MSS, ULG5
Description
SIL1 nucleotide exchange factor (HGNC Symbol)
Entrez gene summary
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]