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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Expression

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Specificity

Cell line

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Specificity

Tissue

Detectable

Cell line

Detectable

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Detectable

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PLS1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PLS1

Gene description

Plastin 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (duodenum, small intestine)
GTEx:Group enriched (colon, small intestine)
FANTOM5:Tissue enriched (small intestine)

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 1 antibody.
HPA055744
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
N/A
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)

GENE INFORMATION

Gene name

PLS1 (HGNC Symbol)

Synonyms

I-plastin, Plastin-1

Description

Plastin 1 (HGNC Symbol)

Entrez gene summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

Chromosome

3

Cytoband

q23

Chromosome location (bp)

142596387 - 142713664

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120756 (version 83.38)

Entrez gene

5357

UniProt

Q14651 (UniProt - Evidence at protein level)

neXtProt

NX_Q14651

Antibodypedia

PLS1 antibodies

PROTEIN BROWSER

PLS1-001
PLS1-002
PLS1-003
PLS1-004
PLS1-005
PLS1-006
PLS1-007
PLS1-008
PLS1-010
PLS1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLS1-001
ENSP00000387890
ENST00000457734
Q14651 [Direct mapping]
Plastin-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005903 [brush border]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
629 aa
70.3 kDa
No 0
PLS1-002
ENSP00000336831
ENST00000337777
Q14651 [Direct mapping]
Plastin-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001951 [intestinal D-glucose absorption]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005903 [brush border]
GO:0032532 [regulation of microvillus length]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902896 [terminal web assembly]
GO:1990357 [terminal web]
Show all
629 aa
70.3 kDa
No 0
PLS1-003
ENSP00000418700
ENST00000497002
Q14651 [Direct mapping]
Plastin-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005903 [brush border]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
629 aa
70.3 kDa
No 0
PLS1-004
ENSP00000419271
ENST00000461644
C9JVY2 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
54 aa
6.3 kDa
No 0
PLS1-005
ENSP00000418880
ENST00000464320
C9J0F3 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
120 aa
13.5 kDa
No 0
PLS1-006
ENSP00000417491
ENST00000497199
C9JAM3 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
53 aa
6.1 kDa
No 0
PLS1-007
ENSP00000419893
ENST00000483373
C9JYI1 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
33 aa
3.8 kDa
No 0
PLS1-008
ENSP00000419531
ENST00000495744
C9JU08 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
58 aa
6.7 kDa
No 0
PLS1-010
ENSP00000417311
ENST00000475296
C9J359 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0051015 [actin filament binding]
Show all
119 aa
13.4 kDa
No 0
PLS1-011
ENSP00000417481
ENST00000476044
C9JAM8 [Direct mapping]
Plastin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
Show all
266 aa
29.5 kDa
No 0

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