Fields »
ABOUT
HELP
BLOG
TMPO

GENERAL INFORMATION

Gene name

 TMPO

Gene description

 Thymopoietin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly abundant expression in the nuclear membranes of most cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008150 , CAB009847
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008150
CAB009847

GENE INFORMATION

Gene name

 TMPO (HGNC Symbol)

Synonyms

 LAP2, LEMD4, TP

Description

 Thymopoietin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 q23.1

Chromosome location (bp)

 98515512 - 98550379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120802 (version 83.38)

Entrez gene

 7112

UniProt

 P42166 (UniProt - Evidence at protein level), P42167 (UniProt - Evidence at protein level)

neXtProt

 NX_P42166, NX_P42167

Antibodypedia

 TMPO antibodies

PROTEIN BROWSER
TMPO-001
TMPO-002
TMPO-005
TMPO-006
TMPO-014
TMPO-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMPO-001
ENSP00000266732
ENST00000266732
P42166 [Direct mapping]
Lamina-associated polypeptide 2, isoform alpha Thymopoietin Thymopentin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 694 aa
75.5 kDa 		No 0
TMPO-002
ENSP00000450627
ENST00000556029
P42167 [Direct mapping]
Lamina-associated polypeptide 2, isoforms beta/gamma Thymopoietin Thymopentin
A0A024RBE7 [Target identity:100%; Query identity:100%]
Thymopoietin, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
Show all
 454 aa
50.7 kDa 		No 1
TMPO-005
ENSP00000376773
ENST00000393053
P42167 [Direct mapping]
Lamina-associated polypeptide 2, isoforms beta/gamma Thymopoietin Thymopentin
A0A024RBH7 [Target identity:100%; Query identity:100%]
Thymopoietin, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
Show all
 345 aa
38.7 kDa 		No 1
TMPO-006
ENSP00000261210
ENST00000261210
P42167 [Direct mapping]
Lamina-associated polypeptide 2, isoforms beta/gamma Thymopoietin Thymopentin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
Show all
 248 aa
27.4 kDa 		No 0
TMPO-014
ENSP00000340251
ENST00000343315
G5E972 [Direct mapping]
Lamina-associated polypeptide 2, isoforms beta/gamma; Thymopoietin, isoform CRA_d
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0016021 [integral component of membrane]
Show all
 414 aa
46.3 kDa 		No 1
TMPO-015
ENSP00000451552
ENST00000556678
H0YJH7 [Direct mapping]
Lamina-associated polypeptide 2, isoforms beta/gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 237 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.