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SOCS2

GENERAL INFORMATION

Gene name

 SOCS2

Gene description

 Suppressor of cytokine signaling 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, K-562, REH)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB010356
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and liver cancer (favourable).
Pancreatic cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010356

GENE INFORMATION

Gene name

 SOCS2 (HGNC Symbol)

Synonyms

 CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2

Description

 Suppressor of cytokine signaling 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 12

Cytoband

 q22

Chromosome location (bp)

 93569814 - 93583487

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120833 (version 83.38)

Entrez gene

 8835

UniProt

 O14508 (UniProt - Evidence at protein level)

neXtProt

 NX_O14508

Antibodypedia

 SOCS2 antibodies

PROTEIN BROWSER
«
SOCS2-001
SOCS2-002
SOCS2-005
SOCS2-006
SOCS2-007
SOCS2-008
SOCS2-009
SOCS2-010
SOCS2-011
SOCS2-012
SOCS2-013
SOCS2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOCS2-001
ENSP00000339428
ENST00000340600
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0
SOCS2-002
ENSP00000448815
ENST00000549206
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0
SOCS2-005
ENSP00000448709
ENST00000548537
F8VS53 [Direct mapping]
Suppressor of cytokine-signaling 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 102 aa
11 kDa 		No 0
SOCS2-006
ENSP00000447161
ENST00000549122
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0
SOCS2-007
ENSP00000442898
ENST00000536696
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0
SOCS2-008
ENSP00000447902
ENST00000548091
F8VU91 [Direct mapping]
Suppressor of cytokine-signaling 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 143 aa
15.8 kDa 		No 0
SOCS2-009
ENSP00000448611
ENST00000549887
F8VRV3 [Direct mapping]
Suppressor of cytokine-signaling 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 161 aa
17.8 kDa 		No 0
SOCS2-010
ENSP00000473902
ENST00000547229
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.4 kDa 		No 0
SOCS2-011
ENSP00000449227
ENST00000551556
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0
SOCS2-012
ENSP00000474805
ENST00000551883
S4R3W1 [Direct mapping]
Suppressor of cytokine-signaling 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 116 aa
13.1 kDa 		No 0
SOCS2-013
ENSP00000474888
ENST00000549510
S4R3Z4 [Direct mapping]
Suppressor of cytokine-signaling 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 46 aa
5.2 kDa 		No 0
SOCS2-201
ENSP00000481249
ENST00000622746
O14508 [Direct mapping]
Suppressor of cytokine signaling 2
A0A024RBD2 [Target identity:100%; Query identity:100%]
Suppressor of cytokine signaling 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005131 [growth hormone receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007259 [JAK-STAT cascade]
GO:0008269 [JAK pathway signal transduction adaptor activity]
GO:0009966 [regulation of signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 198 aa
22.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.