Cell atlas - NFYB - The Human Protein Atlas

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NFYB

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NFYB
Gene description	Nuclear transcription factor Y, beta
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB004211
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB004211	A-431	Nucleoplasm
	CAB004211	U-2 OS	Nucleoplasm
	CAB004211	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	NFYB (HGNC Symbol)
Synonyms	CBF-A, HAP3, NF-YB
Description	Nuclear transcription factor Y, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	104117077 - 104138289
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120837 (version 83.38)
Entrez gene	4801
UniProt	P25208 (UniProt - Evidence at protein level)
neXtProt	NX_P25208
Antibodypedia	NFYB antibodies

PROTEIN BROWSER

NFYB-001	NFYB-003	NFYB-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NFYB-001 ENSP00000240055 ENST00000240055	P25208 [Direct mapping] Nuclear transcription factor Y subunit beta A0A024RBG7 [Target identity:100%; Query identity:100%] Nuclear transcription factor Y, beta, isoform CRA_c Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016602 [CCAAT-binding factor complex] GO:0032403 [protein complex binding] GO:0032993 [protein-DNA complex] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0070491 [repressing transcription factor binding] Show all	207 aa 22.8 kDa	No	0
NFYB-003 ENSP00000447486 ENST00000551727	P25208 [Direct mapping] Nuclear transcription factor Y subunit beta A0A024RBG7 [Target identity:100%; Query identity:100%] Nuclear transcription factor Y, beta, isoform CRA_c Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016602 [CCAAT-binding factor complex] GO:0032993 [protein-DNA complex] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:0070491 [repressing transcription factor binding] Show all	207 aa 22.8 kDa	No	0
NFYB-004 ENSP00000448250 ENST00000551446	F8VSL3 [Direct mapping] Nuclear transcription factor Y subunit beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046982 [protein heterodimerization activity] Show all	131 aa 14.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.