Expression of CCDC53 in cancer - Summary - The Human Protein Atlas

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CCDC53

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC53
Gene description	Coiled-coil domain containing 53
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in smooth muscle and epithelial tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038338 , HPA038339
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038338	HPA038339

GENE INFORMATION
Gene name	CCDC53 (HGNC Symbol)
Synonyms	CGI-116
Description	Coiled-coil domain containing 53 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.2
Chromosome location (bp)	102012927 - 102062149
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120860 (version 83.38)
Entrez gene	51019
UniProt	Q9Y3C0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3C0
Antibodypedia	CCDC53 antibodies

PROTEIN BROWSER

CCDC53-001	CCDC53-002	CCDC53-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC53-001 ENSP00000240079 ENST00000240079	Q9Y3C0 [Direct mapping] WASH complex subunit CCDC53 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0008150 [biological_process] GO:0015031 [protein transport] GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0071203 [WASH complex] Show all	194 aa 21.2 kDa	No	0
CCDC53-002 ENSP00000443857 ENST00000545679	F5GZ97 [Direct mapping] WASH complex subunit CCDC53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0071203 [WASH complex] Show all	193 aa 21 kDa	No	0
CCDC53-012 ENSP00000443922 ENST00000542923	H0YGN0 [Direct mapping] WASH complex subunit CCDC53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071203 [WASH complex] Show all	107 aa 11.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.