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DUSP4

GENERAL INFORMATION

Gene name

 DUSP4

Gene description

 Dual specificity phosphatase 4

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-MEL-30, WM-115)
HPA (normal tissue):Tissue enhanced (breast)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DUSP4 (HGNC Symbol)

Synonyms

 HVH2, MKP-2, TYP

Description

 Dual specificity phosphatase 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p12

Chromosome location (bp)

 29333064 - 29350668

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120875 (version 83.38)

Entrez gene

 1846

UniProt

 Q13115 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13115

Antibodypedia

 DUSP4 antibodies

PROTEIN BROWSER
DUSP4-001
DUSP4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP4-001
ENSP00000240100
ENST00000240100
Q13115 [Direct mapping]
Dual specificity protein phosphatase 4
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000188 [inactivation of MAPK activity]
GO:0001706 [endoderm formation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008330 [protein tyrosine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
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 394 aa
43 kDa 		No 0
DUSP4-002
ENSP00000240101
ENST00000240101
Q13115 [Direct mapping]
Dual specificity protein phosphatase 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000188 [inactivation of MAPK activity]
GO:0001706 [endoderm formation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008330 [protein tyrosine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 303 aa
33 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.