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PTK2B

GENERAL INFORMATION

Gene name

 PTK2B

Gene description

 Protein tyrosine kinase 2 beta

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (REH)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression at variable levels in most cell types, expressed mainly in the brain and lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA026091 , HPA026276 , CAB003850
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and thyroid cancer (favourable).
Cervical cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026091
HPA026276
CAB003850

GENE INFORMATION

Gene name

 PTK2B (HGNC Symbol)

Synonyms

 CADTK, CAKB, FAK2, PTK, PYK2, RAFTK

Description

 Protein tyrosine kinase 2 beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 27311482 - 27459391

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120899 (version 83.38)

Entrez gene

 2185

UniProt

 Q14289 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14289

Antibodypedia

 PTK2B antibodies

PROTEIN BROWSER
PTK2B-001
PTK2B-002
PTK2B-003
PTK2B-007
PTK2B-009
PTK2B-010
PTK2B-011
PTK2B-014
PTK2B-015
PTK2B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTK2B-001
ENSP00000332816
ENST00000346049
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016477 [cell migration]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042976 [activation of Janus kinase activity]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-002
ENSP00000427931
ENST00000517339
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016477 [cell migration]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042976 [activation of Janus kinase activity]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0
PTK2B-003
ENSP00000380634
ENST00000397497
E9PBI4 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 596 aa
68.1 kDa 		No 0
PTK2B-007
ENSP00000416174
ENST00000412793
C9JHV9 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 213 aa
24.9 kDa 		No 0
PTK2B-009
ENSP00000380638
ENST00000397501
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0001556 [oocyte maturation]
GO:0001666 [response to hypoxia]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0006970 [response to osmotic stress]
GO:0007010 [cytoskeleton organization]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0009749 [response to glucose]
GO:0010226 [response to lithium ion]
GO:0010243 [response to organonitrogen compound]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010752 [regulation of cGMP-mediated signaling]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014009 [glial cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016477 [cell migration]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030279 [negative regulation of ossification]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030502 [negative regulation of bone mineralization]
GO:0030826 [regulation of cGMP biosynthetic process]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032403 [protein complex binding]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042976 [activation of Janus kinase activity]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043149 [stress fiber assembly]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071498 [cellular response to fluid shear stress]
GO:0090630 [activation of GTPase activity]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-010
ENSP00000429694
ENST00000522338
E5RHL2 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0045087 [innate immune response]
Show all
 68 aa
7.6 kDa 		No 0
PTK2B-011
ENSP00000428837
ENST00000519512
H0YB74 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 195 aa
21.7 kDa 		No 0
PTK2B-014
ENSP00000430404
ENST00000521164
E5RK84 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 103 aa
11.6 kDa 		No 0
PTK2B-015
ENSP00000428271
ENST00000522517
E5RJ77 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 184 aa
21.5 kDa 		No 0
PTK2B-201
ENSP00000391995
ENST00000420218
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016477 [cell migration]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042976 [activation of Janus kinase activity]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.