Tissue expression of CHRNA2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CHRNA2
Gene description	Cholinergic receptor, nicotinic, alpha 2 (neuronal)
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (prostate)
GTEx:	Tissue enriched (prostate)
FANTOM5:	Tissue enhanced (prostate, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (prostate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, retina)

GENE INFORMATION
Gene name	CHRNA2
Synonyms
Description	Cholinergic receptor, nicotinic, alpha 2 (neuronal) (HGNC Symbol)
Entrez gene summary	Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	27459761 - 27479883
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120903 (version 83.38)
Entrez gene	1135
UniProt	Q15822 (UniProt - Evidence at protein level)
neXtProt	NX_Q15822
Antibodypedia	CHRNA2 antibodies

PROTEIN BROWSER

CHRNA2-001	CHRNA2-004	CHRNA2-006	CHRNA2-008	CHRNA2-009	CHRNA2-010	CHRNA2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRNA2-001 ENSP00000385026 ENST00000407991	Q15822 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0008144 [drug binding] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0035094 [response to nicotine] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0051291 [protein heterooligomerization] GO:0071944 [cell periphery] GO:0098655 [cation transmembrane transport] Show all	529 aa 59.8 kDa	Yes	4
CHRNA2-004 ENSP00000240132 ENST00000240132	Q15822 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0035094 [response to nicotine] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0098655 [cation transmembrane transport] Show all	514 aa 58.1 kDa	Yes	4
CHRNA2-006 ENSP00000429616 ENST00000520933	Q15822 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0035094 [response to nicotine] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0098655 [cation transmembrane transport] Show all	507 aa 57.3 kDa	No	4
CHRNA2-008 ENSP00000429953 ENST00000521921	E5RGP6 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		50 aa 5.3 kDa	Yes	0
CHRNA2-009 ENSP00000430856 ENST00000518712	E5RHQ4 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] Show all	81 aa 8.9 kDa	Yes	0
CHRNA2-010 ENSP00000430994 ENST00000520208	E5RGT4 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	Predicted intracellular proteins Show all		19 aa 2.2 kDa	No	0
CHRNA2-011 ENSP00000430422 ENST00000524096	E5RK67 [Direct mapping] Neuronal acetylcholine receptor subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	108 aa 11.9 kDa	Yes	0