Expression of PDLIM2 in cancer - Summary - The Human Protein Atlas

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PDLIM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDLIM2
Gene description	PDZ and LIM domain 2 (mystique)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003880
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003880

GENE INFORMATION
Gene name	PDLIM2
Synonyms
Description	PDZ and LIM domain 2 (mystique) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22578279 - 22598025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120913 (version 83.38)
Entrez gene	64236
UniProt	Q96JY6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JY6
Antibodypedia	PDLIM2 antibodies

PROTEIN BROWSER

PDLIM2-001	PDLIM2-002	PDLIM2-003	PDLIM2-004	PDLIM2-005	PDLIM2-007	PDLIM2-008	PDLIM2-009	PDLIM2-011	PDLIM2-012	PDLIM2-013	PDLIM2-019	PDLIM2-020	PDLIM2-022	PDLIM2-023	PDLIM2-201	PDLIM2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDLIM2-001 ENSP00000312634 ENST00000308354	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030864 [cortical actin cytoskeleton] GO:0031005 [filamin binding] GO:0032036 [myosin heavy chain binding] GO:0051371 [muscle alpha-actinin binding] GO:0051393 [alpha-actinin binding] GO:0070062 [extracellular exosome] Show all	602 aa 62.7 kDa	No	0
PDLIM2-002 ENSP00000380868 ENST00000397761	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	352 aa 37.5 kDa	No	0
PDLIM2-003 ENSP00000387084 ENST00000409417	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	352 aa 37.5 kDa	No	0
PDLIM2-004 ENSP00000265810 ENST00000265810	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	366 aa 39.2 kDa	No	0
PDLIM2-005 ENSP00000386868 ENST00000409141	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	278 aa 29.1 kDa	No	0
PDLIM2-007 ENSP00000481268 ENST00000464275	B3KPU0 [Direct mapping] PDZ and LIM domain protein 2; cDNA FLJ32186 fis, clone PLACE6002011, highly similar to PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	146 aa 16.1 kDa	No	0
PDLIM2-008 ENSP00000401992 ENST00000456545	C9JSR2 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] Show all	235 aa 24.6 kDa	No	0
PDLIM2-009 ENSP00000394376 ENST00000452226	C9JS55 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] Show all	254 aa 26.8 kDa	No	0
PDLIM2-011 ENSP00000397738 ENST00000436754	C9J760 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	153 aa 16.1 kDa	No	0
PDLIM2-012 ENSP00000392920 ENST00000426493	C9J0X3 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 18.2 kDa	No	0
PDLIM2-013 ENSP00000407643 ENST00000429812	C9K0F0 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	180 aa 18.9 kDa	No	0
PDLIM2-019 ENSP00000478826 ENST00000443561	A0A087WUQ1 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.7 kDa	No	0
PDLIM2-020 ENSP00000380867 ENST00000397760	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	352 aa 37.5 kDa	No	0
PDLIM2-022 ENSP00000478370 ENST00000616289	A0A087WU48 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 1.9 kDa	No	0
PDLIM2-023 ENSP00000477546 ENST00000614502	B3KPU0 [Direct mapping] PDZ and LIM domain protein 2; cDNA FLJ32186 fis, clone PLACE6002011, highly similar to PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	146 aa 16.1 kDa	No	0
PDLIM2-201 ENSP00000342035 ENST00000339162	Q96JY6 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	602 aa 62.7 kDa	No	0
PDLIM2-202 ENSP00000479453 ENST00000622702	A0A087WVI1 [Direct mapping] PDZ and LIM domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	325 aa 34.8 kDa	No	0

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