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Occasional cases of prostate, thyroid, lung and stomach cancers displayed strong cytoplasmic staining. Several cases of carcinoid, prostate, lung, liver, ovarian and urothelial cancers were moderately stained. Remaining cancer tissues were weakly stained or negative.
Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity with additional membranous staining in several cases. Thyroid cancers were strongly stained. Several squamous cell carcinomas, lymphomas, prostate and stomach cancers were negative.
GENE INFORMATION
Gene name
RNF170 (HGNC Symbol)
Synonyms
ADSA, DKFZP564A022, SNAX1
Description
Ring finger protein 170 (HGNC Symbol)
Entrez gene summary
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]